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Proceedings Paper

Finite-element based validation of nonrigid registration using single- and multilevel free-form deformations: application to contrast-enhanced MR mammography
Author(s): Julia Anne Schnabel; Christine Tanner; Andrew D. Castellano-Smith; Andreas Degenhard; Carmel Hayes; Martin O. Leach; D. Rodney Hose; Derek L.G. Hill; David John Hawkes
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Paper Abstract

This work presents a validation study for non-rigid registration of 3D contrast enhanced magnetic resonance mammography images. We are using our previously developed methodology for simulating physically plausible, biomechanical tissue deformations using finite element methods to compare two non-rigid registration algorithms based on single-level and multi-level free-form deformations using B-splines and normalized mutual information. We have constructed four patient-specific finite element models and applied the solutions to the original post-contrast scans of the patients, simulating tissue deformation between image acquisitions. The original image pairs were registered to the FEM-deformed post-contrast images using different free-form deformation mesh resolutions. The target registration error was computed for each experiment with respect to the simulated gold standard on a voxel basis. Registration error and single-level free-form deformation resolution were found to be intrinsically related: the smaller the spacing, the higher localized errors, indicating local registration failure. For multi-level free-form deformations, the registration errors improved for increasing mesh resolution. This study forms an important milestone in making our non-rigid registration framework applicable for clinical routine use.

Paper Details

Date Published: 9 May 2002
PDF: 12 pages
Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); doi: 10.1117/12.467197
Show Author Affiliations
Julia Anne Schnabel, Guy's Hospital/King's College London (United Kingdom)
Christine Tanner, Guy's Hospital/King's College London (United Kingdom)
Andrew D. Castellano-Smith, Guy's Hospital/King's College London (United Kingdom)
Andreas Degenhard, Institute of Cancer Research and Royal Marsden NHS Trust (United Kingdom)
Carmel Hayes, Institute of Cancer Research and Royal Marsden NHS Trust (United Kingdom)
Martin O. Leach, Institute of Cancer Research and Royal Marsden NHS Trust (United Kingdom)
D. Rodney Hose, Univ. of Sheffield (United Kingdom)
Derek L.G. Hill, Guy's Hospital/King's College London (United Kingdom)
David John Hawkes, Guys' Hospital/King's College London (United Kingdom)


Published in SPIE Proceedings Vol. 4684:
Medical Imaging 2002: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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