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Proceedings Paper

Segmentation and classification of normal-appearing brain: how much is enough?
Author(s): John O. Glass; Wilburn E. Reddick; Qing Ji; Lauren S. Glas
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Paper Abstract

In this study, subsets of MR slices were examined to assess their ability to optimally predict the total cerebral volume of gray matter, white matter and CSF. Patients underwent a clinical imaging protocol consisting of T1-, T2-, PD-, and FLAIR-weighted images after obtaining informed consent. MR imaging sets were registered, RF-corrected, and then analyzed with a hybrid neural network segmentation and classification algorithm to identify normal brain parenchyma. After processing the data, the correlation between the image subsets and the total cerebral volumes of gray matter, white matter and CSF were examined. The 29 subjects (18F, 11M) assessed in this study were 1.7 ? 18.7 (median = 5.2) years of age. The five subsets accounted for 5%, 15%, 24%, 56%, and 79% of the total cerebral volume. The predictive correlation for gray matter, white matter, and CSF in each of these subsets were: 5% (R= 0.94, 0.92, 0.91), 15% (R= 0.93, 0.95, 0.94), 24% (R= 0.92, 0.95, 0.94), 56% (R= 0.75, 0.95, 0.89), and 79% (R= 0.89, 0.98, 0.99) respectively. All subsets of slices examined were significantly correlated (p<0.001) with the total cerebral volume of gray matter, white matter, and CSF.

Paper Details

Date Published: 9 May 2002
PDF: 9 pages
Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); doi: 10.1117/12.467161
Show Author Affiliations
John O. Glass, St. Jude Children's Research Hospital (United States)
Wilburn E. Reddick, St. Jude Children's Research Hospital (United States)
Qing Ji, St. Jude Children's Research Hospital (United States)
Lauren S. Glas, St. Jude Children's Research Hospital (United States)


Published in SPIE Proceedings Vol. 4684:
Medical Imaging 2002: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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