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Proceedings Paper

Optimal neural network architecture selection: effects on computer-aided detection of mammographic microcalcifications
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Paper Abstract

We evaluated the effectiveness of an optimal convolution neural network (CNN) architecture selected by simulated annealing for improving the performance of a computer-aided diagnosis (CAD) system designed for the detection of microcalcification clusters on digitized mammograms. The performances of the CAD programs with manually and optimally selected CNNs were compared using an independent test set. This set included 472 mammograms and contained 253 biopsy-proven malignant clusters. Free-response receiver operating characteristic (FROC) analysis was used for evaluation of the detection accuracy. At a false positive (FP) rate of 0.7 per image, the film-based sensitivity was 84.6% with the optimized CNN, in comparison with 77.2% with the manually selected CNN. If clusters having images in both craniocaudal and mediolateral oblique views were analyzed together and a cluster was considered to be detected when it was detected in one or both views, at 0.7 FPs/image, the sensitivity was 93.3% with the optimized CNN and 87.0% with the manually selected CNN. This study indicates that classification of true positive and FP signals is an important step of the CAD program and that the detection accuracy of the program can be considerably improved by optimizing this step with an automated optimization algorithm.

Paper Details

Date Published: 9 May 2002
PDF: 6 pages
Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); doi: 10.1117/12.467095
Show Author Affiliations
Metin Nafi Gurcan, Univ. of Michigan (United States)
Heang-Ping Chan, Univ. of Michigan (United States)
Berkman Sahiner, Univ. of Michigan (United States)
Lubomir M. Hadjiiski, Univ. of Michigan (United States)
Nicholas Petrick, Univ. of Michigan (United States)
Mark A. Helvie, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 4684:
Medical Imaging 2002: Image Processing
Milan Sonka; J. Michael Fitzpatrick, Editor(s)

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