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Proceedings Paper

Thermal imaging of brain tumors in a rat glioma model
Author(s): Thanassis Papaioannou; Reid C. Thompson; Babak Kateb; Oleg Sorokoumov; Warren S. Grundfest; Keith L. Black
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Paper Abstract

We have explored the capability of thermal imaging for the detection of brain tumors in a rat glioma mode. Fourteen Wistar rats were injected stereotactically with 100,000 C6 glioma cells. Approximately one and two weeks post implantation, the rats underwent bilateral craniotomy and the exposed brain surface was imaged with a short wave thermal camera. Thermal images were obtained at both low (approximately 28.7 degree(s)C) and high (approximately 38 degree(s)C) core temperatures. Temperature gradients between the tumor site and the contralateral normal brain were calculated. Overall, the tumors appeared cooler than normal brain, for both high and low core temperatures. Average temperature difference between tumor and normal brain were maximal in more advanced tumors (two weeks) and at higher core temperatures. At one week (N equals 6), the average temperature gradient between tumor and normal sites was 0.1 degree(s)C and 0.2 degree(s)C at low and high core temperatures respectively (P(greater than)0.05). At two weeks (N equals 8), the average temperature gradient was 0.3 degree(s)C and 0.7 degree(s)C at low and high core temperatures respectively (P<0.05). We conclude that thermal imaging can detect temperature differences between tumor and normal brain tissue in this model, particularly in more advanced tumors. Thermal imaging may provide a novel means to identify brain tumors intraoperatively.

Paper Details

Date Published: 13 May 2002
PDF: 4 pages
Proc. SPIE 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, (13 May 2002); doi: 10.1117/12.466653
Show Author Affiliations
Thanassis Papaioannou, Cedars-Sinai Medical Ctr. (United States)
Reid C. Thompson, Cedars-Sinai Medical Ctr. (United States)
Babak Kateb, Cedars-Sinai Medical Ctr. (United States)
Oleg Sorokoumov, Cedars-Sinai Medical Ctr. (United States)
Warren S. Grundfest, Univ. of California/Los Angeles (United States)
Keith L. Black, Cedars-Sinai Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 4615:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV
Tuan Vo-Dinh; David A. Benaron; Warren S. Grundfest, Editor(s)

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