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Proceedings Paper

Solid state lasers for photodynamic therapy of malignant neoplasm
Author(s): Vitaliy M. Khulugurov; Nikolai Ivanov; Byoung-Chul Kim; Alexander Mayorov; Dnitri Bordzilovsky; Valentina Masycheva; Elena Danilenko; Moon-Kwan Chung
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Paper Abstract

This work demonstrates the possibility of treating animals with malignant neoplasms using 608 nm of laser radiation by means of photodynamic therapy (PDT). The intracavity transformation of the Nd:YAP main radiation 1079 nm was Raman converted in barium nitrate crystal, and the Stokes frequency (1216 nm) was doubled using KTP or RTA crystals. The LiF or Cr:YAG crystals are used for the Q-switch. The radiation parameters were obtained at 100 Hz pump repetition frequency. The average power at 608-nm radiation with LiF and KTP was 700 mW at multimode generation. The 3-6 single 10-15 ns pulses were generated during one cycle of pumping. The doubling efficiency with RTA was two times more than with KTP. The cells of Ehrlich adenocarcinoma (0.1 ml) were implanted in hind thighs of ICR white non-imbred mice. Photosensitizer HpD was i.v. administered in a dose of 10 mg/kg. Ten animals were treated (2 as a control). There was a 9-30% decrease in the tumor growth depending on the irradiation dose. The better result (30%) was for the 200 J/cm2 dose radiation. These results show the possibility of using all solid state lasers with wavelength of 608 nm for PDT.

Paper Details

Date Published: 13 May 2002
PDF: 7 pages
Proc. SPIE 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, (13 May 2002); doi: 10.1117/12.466650
Show Author Affiliations
Vitaliy M. Khulugurov, Irkutsk State Univ. (Russia)
Nikolai Ivanov, Irkutsk State Univ. (Russia)
Byoung-Chul Kim, Miryang National Univ. (South Korea)
Alexander Mayorov, Institute of Laser Physics (Russia)
Dnitri Bordzilovsky, Institute of Laser Physics (Russia)
Valentina Masycheva, Institute of Biological Active Materials (Russia)
Elena Danilenko, Institute of Biological Active Materials (Russia)
Moon-Kwan Chung, Yeungnam Univ. College of Medicine (South Korea)

Published in SPIE Proceedings Vol. 4615:
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV
Tuan Vo-Dinh; David A. Benaron; Warren S. Grundfest, Editor(s)

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