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Proceedings Paper

Compact fluorescence spectroscopic tool for cancer detection
Author(s): Valerie Nadeau; Khaled Hamdan; Jacqueline Hewett; Juljia Makaryceva; Iain Tait; Alfred Cuschieri; Miles J. Padgett
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Paper Abstract

We describe a compact fluorescence spectroscopic tool for in vivo point monitoring of aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence and autofluorescence, as a non-invasive method of differentiating normal and cancerous tissue. This instrument incorporates a 405nm diode laser with a shutter to prevent exposure of tissue to harmful light doses and reduce photobleaching, a bifurcated optical fibre to allow illumination of tissue and collection of fluorescence with a single fibre, a compact grating spectrometer for collection of spectra and a PC for system control. We present spectra obtained using this system both during routine gastro-intestinal (GI) endoscopy for cancer detection and during photodynamic therapy (PDT) of anal intraepithelial neoplasia (AIN) for monitoring of treatment progress. These results illustrate the potential of the system to be used for fluorescence monitoring in a variety of clinical applications.

Paper Details

Date Published: 1 May 2002
PDF: 6 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465261
Show Author Affiliations
Valerie Nadeau, Univ. of Glasgow (United Kingdom)
Khaled Hamdan, Ninewells Hospital and Medical School (United Kingdom)
Jacqueline Hewett, Univ. of St. Andrews (United Kingdom)
Juljia Makaryceva, Univ. of Glasgow (United Kingdom)
Iain Tait, Ninewells Hospital and Medical School (United Kingdom)
Alfred Cuschieri, Ninewells Hospital and Medical School (United Kingdom)
Miles J. Padgett, Univ. of Glasgow (United Kingdom)

Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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