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Proceedings Paper

Determination of optical properties in highly attenuating media with an endoscope-compatible reflectance approach
Author(s): T. Joshua Pfefer; L. Stephanie Matchette; Carrie L. Bennett; Joy A. Wilke; Anthony Joseph Durkin; Marwood N. Ediger
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Paper Abstract

Accurate in vivo optical property data in the ultraviolet to visible range are scarce for many endoscope-accessible organs, yet such information is essential for understanding light propagation and identifying dosimetry standards for biomedical optical spectroscopy. We have performed a preliminary study towards the development of a reflectance-based system for endoscopic measurement of tissue optical properties relevant to fluorescence spectroscopy. To address the constraint of instrument channel diameter and strong attenuation of light in the spectral region of interest, maximum fiber separation distance was limited to 2.5 mm. Measurements were performed on tissue phantoms for a range of optical properties relevant to gastrointestinal mucosal tissues in the ultraviolet to visible range: absorption coefficients from 1 to 25 cm-1 and reduced scattering coefficients from 5 to 25 cm-1. Neural network and partial least squares algorithms were trained on radial reflectance profiles generated by a Monte Carlo model as well as by experimental data. These routines were then used to estimate absorption and reduced scattering coefficients from reflectance data. Results are discussed in terms of the optimization of models for optical property determination.

Paper Details

Date Published: 1 May 2002
PDF: 10 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465248
Show Author Affiliations
T. Joshua Pfefer, U.S. Food and Drug Administration (United States)
L. Stephanie Matchette, U.S. Food and Drug Administration (United States)
Carrie L. Bennett, U.S. Food and Drug Administration (United States)
Joy A. Wilke, U.S. Food and Drug Administration (United States)
Anthony Joseph Durkin, Beckman Laser Institute and Medical Clinic (United States)
Marwood N. Ediger, U.S. Food and Drug Administration (United States)

Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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