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Proceedings Paper

Time-resolved fluorescence spectroscopy of human brain tumors
Author(s): Laura Marcu; Reid C. Thompson; Smita Garde; Mark Sedrak; Keith L. Black; William H. Yong
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Paper Abstract

Fluorescence spectroscopy of the endogenous emission of brain tumors has been researched as a potentially important method for the intraoperative localization of brain tumor margins. In this study, we investigate the use of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) for demarcation of primary brain tumors by studying the time-resolved spectra of gliomas of different histologic grades. Time-resolved fluorescence (3 ns, 337 nm excitation) from excised human brain tumor show differences between the time-resolved emission of malignant glioma and normal brain tissue (gray and white matter). Our findings suggest that brain tumors can be differentiated from normal brain tissue based upon unique time-resolved fluorescence signature.

Paper Details

Date Published: 1 May 2002
PDF: 5 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465244
Show Author Affiliations
Laura Marcu, Cedars-Sinai Medical Ctr. and Univ. of Southern California (United States)
Reid C. Thompson, Cedars-Sinai Medical Ctr. (United States)
Smita Garde, Cedars-Sinai Medical Ctr. (United States)
Mark Sedrak, Cedars-Sinai Medical Ctr. (United States)
Keith L. Black, Cedars-Sinai Medical Ctr. (United States)
William H. Yong, Cedars-Sinai Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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