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Proceedings Paper

Simultaneous measurement of photosensitizer absorption and fluorescence in patients undergoing photodynamic therapy
Author(s): Alexander A. Stratonnikov; Natalia V. Ermishova; Gennadii A. Meerovich; Boris V. Kudashev M.D.; Elena G. Vakoulovskaya M.D.; Victor B. Loschenov
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Paper Abstract

This paper deals with photosensitizer quantification in patients undergoing photodynamic therapy. Both fluorescence and diffuse reflectance spectroscopy were applied to evaluate concentration of sulphonated aluminum phthalocyanine in different tissues. The mixtures of Intralipid, blood and photosensitizer with different concentrations were used as standard samples to solve the problem in question. While fluorescence method is more sensitive and more convenient to apply in clinics, the absorption technique may be applied to non fluorescent dyes and used to evaluate the shifts in adsorption peak position due to interaction of dye with tissues. Finally, the concentration dynamics of non fluorescent dye (cobalt phthalocyanine) in patients was obtained with the use of absorption method alone.

Paper Details

Date Published: 1 May 2002
PDF: 12 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465242
Show Author Affiliations
Alexander A. Stratonnikov, General Physics Institute (Russia)
Natalia V. Ermishova, General Physics Institute (Russia)
Gennadii A. Meerovich, General Physics Institute (Russia)
Boris V. Kudashev M.D., Cancer Research Ctr. (Russia)
Elena G. Vakoulovskaya M.D., Cancer Research Ctr. (Russia)
Victor B. Loschenov, General Physics Institute (Russia)

Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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