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Proceedings Paper

Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy
Author(s): Reid C. Thompson; Keith L. Black; Babak Kateb; Laura Marcu
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Paper Abstract

Time-Resolved Laser-Induced Fluorescence Spectroscopy (TR-LIFS) has the potential to provide a non- invasive characterization and detection of tumors. We utilized TR-LIFS to detect gliomas in-vivo in the rat C6 glioma model. Time-resolved emission spectra of both normal brain and tumor were analyzed to determine if unique fluorescence signatures could be used to distinguish the two. Fluorescence parameters derived from both spectral and time domain were used for tissue characterization. Our results show that in the rat C6 glioma model, TR-LIFS can be used to differentiate brain tumors from normal tissue (gray and white mater) based upon time- resolved fluorescence signatures seen in brain tumors.

Paper Details

Date Published: 1 May 2002
PDF: 5 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465236
Show Author Affiliations
Reid C. Thompson, Cedars-Sinai Medical Ctr. (United States)
Keith L. Black, Cedars-Sinai Medical Ctr. (United States)
Babak Kateb, Cedars-Sinai Medical Ctr. (United States)
Laura Marcu, Cedars-Sinai Medical Ctr. and Univ. of Southern California (United States)

Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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