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Proceedings Paper

Diffuse reflectance spectroscopy to quantify inflammation of the oral epithelium In Vivo
Author(s): David W. Hattery; Kristin Gerdelman; Farid Hekmat; Victor V. Chernomordik; Paul D. Smith; Alec B. Eidsath; Randy Pursley; Jane Atkinson; James Mulshine; Amir H. Gandjbakhche
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Paper Abstract

Recent studies suggest that inflammatory cell products may contribute to the evolution of particular cancers leading to new chemoprevention trials exploring the benefit of anti-inflammatory drugs such as aspirin and related products. As part of a prospective trial evaluating this anti-inflammatory strategy for oral cancer, we evaluated a non-invasive optical system to determine if we could use an indirect measure of oral inflammation, mucosal thickness, as a monitoring parameter to evaluate the effectiveness of anti-inflammatory drug therapy. Diffuse reflectance spectroscopy has the potential for probing near-surface structures, however, traditional methods for accounting for scattering of photons are generally invalid for typical epithelial thicknesses. Monte Carlo simulations have shown that, with proper scaling, a simple photon model may be used to predict photon behavior under these conditions. A differential measure, which is very sensitive to small changes, has been shown to have the potential to quantify epithelial thickness. A simple prototype device has been brought from desk, to bench and bedside in a rapid manner to fill a need for a non-invasive measure of oral inflammation. From the theory, a simple feature has been identified that corresponds to patient oral inflammation. Preliminary results from this work are presented and indicate that further development of the approach to enable quantification of epithelial thickness in vivo is warranted.

Paper Details

Date Published: 1 May 2002
PDF: 12 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465230
Show Author Affiliations
David W. Hattery, National Institute of Child Health and Human Development/National Institutes of Health (United States)
Kristin Gerdelman, National Institute of Child Health and Human Development/National Institutes of Health (United States)
Farid Hekmat, National Institute of Child Health and Human Development/National Institutes of Health (United States)
Victor V. Chernomordik, National Institute of Child Health and Human Development/National Institutes of Health (Israel)
Paul D. Smith, National Institute of Child Health and Human Development/National Institutes of Health (United States)
Alec B. Eidsath, National Institute of Child Health and Human Development/National Institutes of Health (United States)
Randy Pursley, National Institute of Child Health and Human Development/National Institutes of Health (United States)
Jane Atkinson, Baltimore College of Dental Surgery/Univ. of Maryland (United States)
James Mulshine, National Cancer Insitute/National Institutes of Health (United States)
Amir H. Gandjbakhche, National Cancer Insitute/National Institutes of Health (Israel)


Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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