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Proceedings Paper

Noninvasive fluorescence and Raman spectroscopic analysis of laser welded aorta and skin tissue
Author(s): Alvin Katz; Tapan K. Gayen; Glenn Minko; Alexandra Alimova; Howard E. Savage; Steven A. McCormick; Robert R. Alfano
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Paper Abstract

Laser tissue welding involves the denaturing and partial renaturing of collagen and elastin. Tissues welded with NIR lasers tuned to the 1455 nm water absorption band have demonstrated high tensile strength with minimal collateral damage. To better understand the welding process, welded tissue samples were investigated using fluorescence imaging and Raman spectroscopy. As part of this study, human aorta, and porcine aorta and skin, specimens were investigated. Emission and excitation/emission wavelengths corresponding to tryptophan and collagen emission and slightly weaker emission for wavelengths corresponding to elastin emission. The inner surface an cross-section images of the aortic specimens exhibited a very high degree of uniformity with no indication of the presence of a weld. The Raman spectra from the aortic specimens at the weld site and a few mm away form the weld were very similar. This work indicates the emission and Raman properties of the collagen helix after welding are very similar to native collagen tissue.

Paper Details

Date Published: 1 May 2002
PDF: 3 pages
Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); doi: 10.1117/12.465228
Show Author Affiliations
Alvin Katz, CUNY/City College (United States)
Tapan K. Gayen, CUNY/City College (United States)
Glenn Minko, CUNY/City College (United States)
Alexandra Alimova, CUNY/City College (United States)
Howard E. Savage, New York Eye and Ear Infirmary (United States)
Steven A. McCormick, New York Eye and Ear Infirmary (United States)
Robert R. Alfano, CUNY/City College (United States)

Published in SPIE Proceedings Vol. 4613:
Optical Biopsy IV
Robert R. Alfano, Editor(s)

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