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Proceedings Paper

Probing brain cancer by fiber optic FTIR spectroscopy
Author(s): Gerald Steiner; Angelique Kano; Tom Richter; Ralf Bergmann; Heike Rodig; Jens Kobelke; Bernd Johannsen; Reiner Salzer
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Paper Abstract

The use of several silver halide and chalcogenide infrared transmitting fibers in the detection of cancer is investigated. As a test sample for all types of fibers we used a thin section of an entire rat brain with glioblastoma. Moving the sample with an XY stage maps across the whole tissue section with more than 200 spectra were recorded. Data evaluation was performed using Principal Components Analysis (PCA). The silver halide fibers have provided excellent results. The tumor was clearly differentiable from the normal tissue. It wasn't possible to identify the tumor region using chalcogenide fibers because the fiber has a very low transmittance in the important fingerprint region.

Paper Details

Date Published: 26 March 2002
PDF: 7 pages
Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); doi: 10.1117/12.463822
Show Author Affiliations
Gerald Steiner, Technische Univ. Dresden (Germany)
Angelique Kano, Technische Univ. Dresden (United States)
Tom Richter, Technische Univ. Dresden (Germany)
Ralf Bergmann, Forschungszentrum Rossendorf (Germany)
Heike Rodig, Forschungszentrum Rossendorf (Germany)
Jens Kobelke, Institut fuer Physikalische Hochtechnologie e.V. (Germany)
Bernd Johannsen, Forschungszentrum Rossendorf (Germany)
Reiner Salzer, Technische Univ. Dresden (Germany)


Published in SPIE Proceedings Vol. 4616:
Optical Fibers and Sensors for Medical Applications II
Israel Gannot, Editor(s)

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