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Proceedings Paper

Hollow-waveguide-based laser-to-ultrasound transducer for drug delivery application
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Paper Abstract

A COP (cyclic olefin polymer)-coated silver hollow waveguide was used to transmit 1064-nm nanosecond laser pulses that irradiated a metal target to produce an ultrasound wave (stress wave) through plasma formation on the target. Porcine gastric and myocardium tissues, on which a solution of rhodamine-B isothiocyanate-dextran (10 kDa) was dropped, were exposed to the stress wave. Much deeper drug penetration was observed for the tissues exposed the stress wave than for the tissues without stress wave exposure.

Paper Details

Date Published: 26 March 2002
PDF: 5 pages
Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); doi: 10.1117/12.463814
Show Author Affiliations
Shunichi Sato, National Defense Medical College Research Institute (Japan)
Makoto Ogura, Keio Univ. (Japan)
Minoru Obara, Keio Univ. (Japan)
Yi-Wei Shi, Tohoku Univ. (Japan)
Yuji Matsuura, Tohoku Univ. (Japan)
Mitsunobu Miyagi, Tohoku Univ. (Japan)
Hiroshi Ashida, National Defense Medical College Research Institute (Japan)


Published in SPIE Proceedings Vol. 4616:
Optical Fibers and Sensors for Medical Applications II
Israel Gannot, Editor(s)

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