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Proceedings Paper

Dynamic MR mammography: multidimensional visualization of contrast enhancement in virtual reality
Author(s): Gesine Hellwig; Karl-Hans Englmeier; Juergen Griebel; Robert Lucht; Stefan Delorme; Markus Siebert; Gunnar Brix
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Paper Abstract

The purpose of this study was the development of a method for fast and efficient analysis of dynamic MR images of the female breast. The image data sets were acquired with a saturation-recovery turbo-FLASH sequence facilitating the detection of the kinetics of the contrast agent concentration in the whole breast with a high temporal and spatial resolution. In addition, a morphological 3D-FLASH data set was acquired. The dynamic image data sets were analyzed by tracer kinetic modeling in order to describe the physiological processes underlying the contrast enhancement in mathematical terms and thus to enable the estimation of functional tissue specific parameters, reflecting the status of microcirculation. In order to display morphological and functional tissue information simultaneously, we developed a multidimensional visualization system, which enables a practical and intuitive human-computer interface in virtual reality. The quality of real-time volume visualization (using 3D-texture mapping) mainly depends on two factors: number and spatial resolution of the sampling slices. Furthermore, to allow the representation of both the MR signal and the relevant set of model parameters, an adaptation of these quantities to the size of the texture element might be necessary. - Detection and localization of multiple breast lesions may be an important application.

Paper Details

Date Published: 24 April 2002
PDF: 8 pages
Proc. SPIE 4683, Medical Imaging 2002: Physiology and Function from Multidimensional Images, (24 April 2002); doi: 10.1117/12.463612
Show Author Affiliations
Gesine Hellwig, Forschungszentrum fuer Umwelt und Gesundheit and Bundesantes fuer Strahlenschutz (Germany)
Karl-Hans Englmeier, Forschungszentrum fuer Umwelt und Gesundheit (Germany)
Juergen Griebel, Bundesantes fuer Strahlenschutz (Germany)
Robert Lucht, Bundesantes fuer Strahlenschutz (Germany)
Stefan Delorme, Deutsches Krebforschungszentrum (Germany)
Markus Siebert, Forschungszentrum fuer Umwelt und Gesundheit (Germany)
Gunnar Brix, Bundesantes fuer Strahlenschutz (Germany)


Published in SPIE Proceedings Vol. 4683:
Medical Imaging 2002: Physiology and Function from Multidimensional Images
Anne V. Clough; Chin-Tu Chen, Editor(s)

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