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Proceedings Paper

Knowledge-based approach for functional MRI analysis by SOM neural network using prior labels from Talairach stereotaxic space
Author(s): Stephan G. Erberich; Klaus Willmes; Armin Thron; Walter Oberschelp; H. K. Huang
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Paper Abstract

Among the methods proposed for the analysis of functional MR we have previously introduced a model-independent analysis based on the self-organizing map (SOM) neural network technique. The SOM neural network can be trained to identify the temporal patterns in voxel time-series of individual functional MRI (fMRI) experiments. The separated classes consist of activation, deactivation and baseline patterns corresponding to the task-paradigm. While the classification capability of the SOM is not only based on the distinctness of the patterns themselves but also on their frequency of occurrence in the training set, a weighting or selection of voxels of interest should be considered prior to the training of the neural network to improve pattern learning. Weighting of interesting voxels by means of autocorrelation or F-test significance levels has been used successfully, but still a large number of baseline voxels is included in the training. The purpose of this approach is to avoid the inclusion of these voxels by using three different levels of segmentation and mapping from Talairach space: (1) voxel partitions at the lobe level, (2) voxel partitions at the gyrus level and (3) voxel partitions at the cell level (Brodmann areas). The results of the SOM classification based on these mapping levels in comparison to training with all brain voxels are presented in this paper.

Paper Details

Date Published: 24 April 2002
PDF: 11 pages
Proc. SPIE 4683, Medical Imaging 2002: Physiology and Function from Multidimensional Images, (24 April 2002); doi: 10.1117/12.463603
Show Author Affiliations
Stephan G. Erberich, RWTH-Aachen (United States)
Klaus Willmes, RWTH-Aachen (Germany)
Armin Thron, RWTH-Aachen (Germany)
Walter Oberschelp, Childrens Hospital Los Angeles/Univ. of Southern Callifornia (Germany)
H. K. Huang, Childrens Hospital Los Angeles/Univ. of Southern California (United States)

Published in SPIE Proceedings Vol. 4683:
Medical Imaging 2002: Physiology and Function from Multidimensional Images
Anne V. Clough; Chin-Tu Chen, Editor(s)

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