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Proceedings Paper

Characterization of pulmonary microcirculation according to hemodynamic changes with computed tomography
Author(s): Byoung Wook Choi; Kyu Ok Choe; Hee-Joung Kim; Bum Koo Cho; Kyung Young Chung; Se Kyu Kim; Bong Kyung Kim; In Sook Yang
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Paper Abstract

The common and important change of pulmonary hemodynamics is represented by increased or decreased pulmonary blood flow (PBF) and increased pulmonary vascular resistance (PVR). We made 3 hemodynamic models in 5 dogs, that is, increased and decreased PBF model and increased PVR model. CT perfusion scan was performed. Perfusion parameters including blood flow (BF), blood volume (BV), mean transit time (MTT), and maximal slope (MS) were analyzed. In normal state, blood flow was affected by gravity and dependent area showed higher BF, BV and lower MS, MTT than non-dependent area. First, decreased PBF model showed no significant change in BV and elongation of MTT. Secondly, increased PBF model showed slightly increased BV and decreased MTT. Thirdly, increased PVR model showed significant decrease of BF, BV, and MS and slight increase of MTT without statistical significance. However, it was noticeable that the distribution of MTT according to gravity in normal lung was completely reversed in increased PVR model. In conclusion, on the basis of our understanding of perfusion characteristic in normal state, we can detect and evaluate the abnormal regional hemodynamic change in lung. Predicting the change of pulmonary vascular resistance should be possible by thorough analysis of CT perfusion parameters.

Paper Details

Date Published: 24 April 2002
PDF: 12 pages
Proc. SPIE 4683, Medical Imaging 2002: Physiology and Function from Multidimensional Images, (24 April 2002); doi: 10.1117/12.463574
Show Author Affiliations
Byoung Wook Choi, Yonsei Univ. College of Medicine (South Korea)
Kyu Ok Choe, Yonsei Univ. College of Medicine (South Korea)
Hee-Joung Kim, Yonsei Univ. College of Medicine (South Korea)
Bum Koo Cho, Yonsei Univ. College of Medicine (South Korea)
Kyung Young Chung, Yonsei Univ. College of Medicine (South Korea)
Se Kyu Kim, Yonsei Univ. College of Medicine (South Korea)
Bong Kyung Kim, Yonsei Univ. College of Medicine (South Korea)
In Sook Yang, Yonsei Univ. College of Medicine (South Korea)


Published in SPIE Proceedings Vol. 4683:
Medical Imaging 2002: Physiology and Function from Multidimensional Images
Anne V. Clough; Chin-Tu Chen, Editor(s)

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