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Proceedings Paper

Interobserver variations on interpretation of multislice CT lung cancer screening studies, and the implications for computer-aided diagnosis
Author(s): Carol L. Novak; JianZhong Qian; Li Fan; Jane P. Ko; Ami N. Rubinowitz; Georgeann McGuinness; David Naidich
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Paper Abstract

With low dose multi-slice CT for screening of lung cancer, physicians are now finding and examining increasingly smaller nodules. However as the size of detectable nodules becomes smaller, there may be greater differences among physicians as to what is detected and what constitutes a nodule. In this study, 10 CT screening studies of smokers were individually evaluated by three thoracic radiologists. After consensus to determine a gold standard, the number of nodules detected by individual radiologists ranged from 1.4 to 2.1 detections per patient. Each radiologist detected nodules missed by the other two. Although a total of 26 true nodules were detected by one or more radiologists, only 8 (31%) were detected by all three radiologists. The number of true nodules detected by an integrated automatic detection algorithm was 3.2 per patient after radiologist validation. Including these nodules in the gold standard set reduced the sensitivity of nodule detection by each radiologist to less than half. The sensitivity of nodule detection by the computer was better at 64%, proving especially efficacious for detecting smaller and more central nodules. Use of the automatic detection module would allow individual radiologists to increase the number of detected nodules by 114% to 207%.

Paper Details

Date Published: 12 April 2002
PDF: 12 pages
Proc. SPIE 4686, Medical Imaging 2002: Image Perception, Observer Performance, and Technology Assessment, (12 April 2002); doi: 10.1117/12.462663
Show Author Affiliations
Carol L. Novak, Siemens Corporate Research, Inc. (United States)
JianZhong Qian, Siemens Corporate Research, Inc. (United States)
Li Fan, Siemens Corporate Research, Inc. (United States)
Jane P. Ko, New York Univ. Medical Ctr. (United States)
Ami N. Rubinowitz, New York Univ. Medical Ctr. (United States)
Georgeann McGuinness, New York Univ. Medical Ctr. (United States)
David Naidich, New York Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 4686:
Medical Imaging 2002: Image Perception, Observer Performance, and Technology Assessment
Dev Prasad Chakraborty; Elizabeth A. Krupinski, Editor(s)

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