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Proceedings Paper

99mTc-HYNIC-TNF analogs (WH701) derived from phage display peptide libraries for imaging TNF-receptor-positive ovarian carcinoma: preclinical evaluation
Author(s): Yan Xiang; Jinsong Xia; H. Wu; H. F. Li
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Paper Abstract

Radiolabeled bioactive peptides which bind specifically to surface receptors over expressed in tumor cells are considered as alternatives for tumor detection with ECT. In this investigation, 99mTc-hydrazinonicotinyl - TNF analogs (WH701) was labeled using ethylenediaminediacetic acid (EDDA) as coligand (a number of TNF analogs had been selected and synthesized using random phage-display peptides library in our lab) and Pharmacokinetics and feasibility studies were performed.

Paper Details

Date Published: 12 April 2002
PDF: 6 pages
Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); doi: 10.1117/12.462569
Show Author Affiliations
Yan Xiang, Huazhong Univ. of Science and Technology (China)
Jinsong Xia, Huazhong Univ. of Science and Technology (China)
H. Wu, Huazhong Univ. of Science and Technology (China)
H. F. Li, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 4536:
International Workshop on Photonics and Imaging in Biology and Medicine

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