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Proceedings Paper

Monitoring of tissue modification with optical coherence tomography
Author(s): Wei Zhang; Qingming Luo; Lei Yao; Haiying Cheng; Shaoqun Zeng
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Paper Abstract

An experimental monitoring of tissue modification of in vitro and in vivo rabbit dura mater with administration of osmotical agents, 40% glucose solution and glycerol, using optical coherence tomography was presented. The preliminary results of experimental study of influence of osmotical liquids (glucose solutions, glycerol) of rabbit dura mater were reported. The significant decreasing of the light from surface and increasing of the light from the deep of dura mater under action of osmotical solutions and the increasing of OCT imaging depth were demonstrated. Experiments showed that administration of osmolytes to dura mater allowed for effective and temporary control of its optical characteristics, which made dura mater more transparent, increased the ability of light penetrating the tissue, and consequently improved the optical imaging depth. It is a significant study, which can improve penetration of optical imaging of cerebral function and acquire more information of the deep brain tissue.

Paper Details

Date Published: 12 April 2002
PDF: 5 pages
Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); doi: 10.1117/12.462560
Show Author Affiliations
Wei Zhang, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Lei Yao, Huazhong Univ. of Science and Technology (China)
Haiying Cheng, Huazhong Univ. of Science and Technology (China)
Shaoqun Zeng, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 4536:
International Workshop on Photonics and Imaging in Biology and Medicine

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