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Proceedings Paper

Calibration of tissue optical properties for I&Q phase detection system using multiwavelength fitting model
Author(s): Ping Huang; Shoko Nioka; Britton Chance
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Paper Abstract

In-phase and Quadrature Phase Detection System (I&Q System) can be used to detect the clinic-related parameters such as hemoglobin concentration and saturation. We set up an effective multi-wavelength fitting model and method to calibrate the tissue optical properties such as the reduced scattering factor ((mu) s) and the absorption factor ((mu) a), which can be calculated from the measured amplitude and phase shift of I&Q system. Then using the calibrated tissue optical parameters, we can get better results for hemoglobin concentration and saturation by our proposed algorithm of fitting multi-wavelength absorption coefficient ((mu) a) of the medium than those from the previous I&Q system based on the two-wavelength absorption coefficient calculation. Our algorithm is used in the clinical experiments with five wavelengths (680 nm, 750 nm, 780 nm, 810 nm, 830 nm) for the necks' and arms' saturation test between normal persons and tumor-bearing patients.

Paper Details

Date Published: 12 April 2002
PDF: 12 pages
Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); doi: 10.1117/12.462548
Show Author Affiliations
Ping Huang, Univ. of Pennsylvania and Northern Jiaotong Univ. (United States)
Shoko Nioka, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 4536:
International Workshop on Photonics and Imaging in Biology and Medicine
Qingming Luo; Britton Chance; Valery V. Tuchin, Editor(s)

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