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Proceedings Paper

Comparison of in-vivo optical imaging of brain functional activity: intrinsic signal imaging and laser speckle imaging
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Paper Abstract

At present, the easiest and most effective strategy of imaging functional architecture is based on the slow intrinsic changes in the optical properties of active brain tissue, permitting visualization of active cortical regions at a spatial resolution better than 50 micrometers . This can be accomplished without some of the problems associated with the use of extrinsic probes. Monitoring the spatio-temporal characteristics of cerebral blood flow (CBF) is crucial for studying the normal and pathological conditions of brain metabolism. Laser dynamic speckle imaging technique achieves this goal without the need for scanning by utilizing the spatial statistics of time-integrated speckle, which was first proposed by Fercher and Briers in the early eighties. Considering similarity of these two experimental systems, we are trying to integrate them into one system in order to acquire much more neurophysiological information simultaneously.

Paper Details

Date Published: 12 April 2002
PDF: 5 pages
Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); doi: 10.1117/12.462531
Show Author Affiliations
Zheng Wang, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Haiying Cheng, Huazhong Univ. of Science and Technology (China)

Published in SPIE Proceedings Vol. 4536:
International Workshop on Photonics and Imaging in Biology and Medicine
Qingming Luo; Britton Chance; Valery V. Tuchin, Editor(s)

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