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Proceedings Paper

Characterization of biological structures with nonlinear chemical imaging nanomicroscopy
Author(s): Richard D. Schaller; Justin Johnson; Kevin R. Wilson; Lynn Lee; Louie Haber; Richard J. Saykally
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Paper Abstract

Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

Paper Details

Date Published: 1 April 2002
PDF: 7 pages
Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, (1 April 2002); doi: 10.1117/12.461388
Show Author Affiliations
Richard D. Schaller, Univ. of California/Berkeley (United States)
Justin Johnson, Univ. of California/Berkeley (United States)
Kevin R. Wilson, Univ. of California/Berkeley (United States)
Lynn Lee, Univ. of California/Berkeley (United States)
Louie Haber, Univ. of California/Berkeley (United States)
Richard J. Saykally, Univ. of California/Berkeley (United States)

Published in SPIE Proceedings Vol. 4633:
Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers
Joseph Neev; Andreas Ostendorf; Glenn S. Edwards; Joseph Neev; Andreas Ostendorf; John Clark Sutherland, Editor(s)

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