Share Email Print

Proceedings Paper

Characterization of biological structures with nonlinear chemical imaging nanomicroscopy
Author(s): Richard D. Schaller; Justin Johnson; Kevin R. Wilson; Lynn Lee; Louie Haber; Richard J. Saykally
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

Paper Details

Date Published: 1 April 2002
PDF: 7 pages
Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, (1 April 2002); doi: 10.1117/12.461388
Show Author Affiliations
Richard D. Schaller, Univ. of California/Berkeley (United States)
Justin Johnson, Univ. of California/Berkeley (United States)
Kevin R. Wilson, Univ. of California/Berkeley (United States)
Lynn Lee, Univ. of California/Berkeley (United States)
Louie Haber, Univ. of California/Berkeley (United States)
Richard J. Saykally, Univ. of California/Berkeley (United States)

Published in SPIE Proceedings Vol. 4633:
Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers
Joseph Neev; Glenn S. Edwards; Joseph Neev; Andreas Ostendorf; Andreas Ostendorf; John Clark Sutherland, Editor(s)

© SPIE. Terms of Use
Back to Top