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Proceedings Paper

Comparison of OPO and Mark-III FEL for tissue ablation at 6.45 um
Author(s): Glenn S. Edwards; M. Shane Hutson; Susanne Hauger; John A. Kozub; Jin-Hui Shen; Charles Shieh; Katie Topadze; Karen Joos
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Paper Abstract

We have investigated the experimental consequences of two picosecond infrared lasers, both tuned to 6.45micrometers and focused on ocular tissue. The exposure conditions were comparable, other than pulse repetition rate, where an optical parametric oscillator/amplifier laser (OPA) system operates at a kilohertz and the Mark-III FEL at 3 gigahertz. In both cases, the peak intensity was near 2x1014 W/m2 and the total delivered energy was approximately 125 mJ. The Mark-III consistently ablates tissue, while the OPA fails to ablate or to damage corneal tissue. In particular, there is no experimental evidence for protein denaturation due to OPA irradiation. WE account for these observations in terms of a theoretical model based on thermal diffusion and threshold conditions for superheating and chemical kinetics. We comment on the relevance of tissue geometry.

Paper Details

Date Published: 1 April 2002
PDF: 7 pages
Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers, (1 April 2002); doi: 10.1117/12.461379
Show Author Affiliations
Glenn S. Edwards, Duke Univ. (United States)
M. Shane Hutson, Duke Univ. (United States)
Susanne Hauger, Duke Univ. (United States)
John A. Kozub, Vanderbilt Univ. (United States)
Jin-Hui Shen, Vanderbilt Univ. (United States)
Charles Shieh, Vanderbilt Univ. (United States)
Katie Topadze, Vanderbilt Univ. (United States)
Karen Joos, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 4633:
Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers
Joseph Neev; Glenn S. Edwards; Joseph Neev; Andreas Ostendorf; Andreas Ostendorf; John Clark Sutherland, Editor(s)

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