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Proceedings Paper

Near-infrared Raman spectroscopy for detection and classification of gastrointestinal disease
Author(s): Nicholas Stone; Catherine A. Kendall; Nitya Chandratreya; Neil Shepherd; Hugh Barr
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Paper Abstract

The prospect of utilising NIR-Raman spectroscopy for analysis of gastro-intestinal (GI) tissue has been explored both with snap-frozen and formalin fixed samples. In the oesophagus large sample numbers have been employed and the full spectrum of pathology has been studied. Multivariate analysis techniques have been employed to optimally separate the groups and spectral diagnostic models have been constructed and evaluated by employing cross-validation testing. Sensitivities have been shown to vary between 73 and 100 percent and specificities between 91 and 100 percent, depending on pathology group and tissue type.

Paper Details

Date Published: 27 March 2002
PDF: 10 pages
Proc. SPIE 4614, Biomedical Vibrational Spectroscopy II, (27 March 2002); doi: 10.1117/12.460788
Show Author Affiliations
Nicholas Stone, Cranfield Postgraduate Medical School (United Kingdom)
Catherine A. Kendall, Cranfield Postgraduate Medical School (United Kingdom)
Nitya Chandratreya, Princess Margaret Hospital (United Kingdom)
Neil Shepherd, Cranfield Postgraduate Medical School and Gloucestershire Royal Hospital (United Kingdom)
Hugh Barr, Cranfield Postgraduate Medical Schooland Gloucestershire Royal Hospital (United Kingdom)


Published in SPIE Proceedings Vol. 4614:
Biomedical Vibrational Spectroscopy II
Anita Mahadevan-Jansen; Henry H. Mantsch; Gerwin J. Puppels, Editor(s)

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