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Proceedings Paper

Origins of the protein synthesis machinery: a genomics and structural perspective
Author(s): George E. Fox; James Hury; Uma Nagaswamy; Jiachen Wang; Ashwinikumar K. Naik
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Paper Abstract

The protein synthesis machinery is believed to have largely evolved before the last common ancestor of life on Earth as we know it. Thus, an understanding of ribosomal history will provide insight to the transition period between the last common ancestor and the RNA World. It is argued here that much of this history has been preserved in the primary sequences and three-dimensional structures of the various ribosomal components. In order to understand this history, it is necessary to identify timing insights that can provide clues to the relative age of various aspects of the ribosomal machinery. Such information can be obtained in a variety of ways. Several examples of how such information might be obtained are discussed. Finally, a tentative outline of the order of major events in ribosome history is presented.

Paper Details

Date Published: 26 February 2003
PDF: 9 pages
Proc. SPIE 4859, Instruments, Methods, and Missions for Astrobiology V, (26 February 2003); doi: 10.1117/12.457570
Show Author Affiliations
George E. Fox, Univ. of Houston (United States)
James Hury, Univ. of Houston (United States)
Uma Nagaswamy, Univ. of Houston (United States)
Jiachen Wang, Univ. of Houston (United States)
Ashwinikumar K. Naik, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 4859:
Instruments, Methods, and Missions for Astrobiology V
Richard B. Hoover; Alexei Yu. Rozanov; Roland R. Paepe, Editor(s)

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