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Proceedings Paper

Amplifying fluorescent polymer detection of bioanalytes
Author(s): Lawrence F. Hancock; Robert Deans; Joongho Moon; Timothy M. Swager
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Paper Abstract

Nomadics and Professor Timothy Swager have collaborated extensively on the development of Amplifying Fluorescent Polymer (AFP) sensing technologies. AFPs are fully conjugated polymers which link many fluorphores into what is in effect, a molecular wire. Once linked, the ensemble of fluorophores will respond to a transduction event at any individual fluorophore. As a result, each individual analyte interaction will produce an effect in a much larger ensemble of fluorphores, amplifying each sensing event. Nomadics capitalized on this effect to construct a handheld landmine detector, which can identify buried landmines by sensing the trace signature of TNT vapor emanating from a mine. This presentation will describe efforts of Nomadics and the Swager group to leverage the intrinsic amplification of AFP systems for bioanalyte detection.

Paper Details

Date Published: 21 February 2002
PDF: 5 pages
Proc. SPIE 4575, Chemical and Biological Early Warning Monitoring for Water, Food, and Ground, (21 February 2002); doi: 10.1117/12.456910
Show Author Affiliations
Lawrence F. Hancock, Nomadics, Inc. (United States)
Robert Deans, Nomadics, Inc. (United States)
Joongho Moon, Nomadics, Inc. (United States)
Timothy M. Swager, Massachusetts Institute of Technology (United States)

Published in SPIE Proceedings Vol. 4575:
Chemical and Biological Early Warning Monitoring for Water, Food, and Ground
Janet L. Jensen; Larry W. Burggraf, Editor(s)

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