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Proceedings Paper

Evaluation of x-ray detectors for dual-modality CT-SPECT animal imaging
Author(s): Lawrence R. MacDonald; Koji Iwata; Bradley E. Patt; Jan S. Iwanczyk; Andrew B. Hwang; Max C. Wu; Bruce H. Hasegawa
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Paper Abstract

We are developing a bench-top animal scanner that will acquire both functional SPECT images and anatomical CT images with sub-millimeter spatial resolution for both imaging modalities. This paper presents preliminary results from the evaluation of two x-ray detectors for the CT application, and dual SPECT-CT images using one of these detectors. Two phosphor-CMOS x-ray detectors, one with 48 m pixels and 5 cm x 5 cm area and the other with 50 μm pixels and 12 cm x 12 cm area, were evaluated for linearity and dynamic range. Each detector showed linearity over ~ 3 orders of magnitude, which is sufficient for mouse CT imaging. The smaller detector was mounted to an A-SPECT system, along with a custom 50 W x-ray source with focal spot size of ~ 150 μm. Phantoms and mice were scanned sequentially, SPECT followed by CT, and the resulting reconstructed images fused into a single SPECT-CT image. These preliminary results show that the two detectors evaluated for this application can successfully achieve high contrast CT images of mice and similar sized objects.

Paper Details

Date Published: 26 November 2002
PDF: 12 pages
Proc. SPIE 4786, Penetrating Radiation Systems and Applications IV, (26 November 2002); doi: 10.1117/12.456316
Show Author Affiliations
Lawrence R. MacDonald, Photon Imaging, Inc. (United States)
Koji Iwata, Univ. of California/San Francisco (United States)
Bradley E. Patt, Photon Imaging, Inc. (United States)
Jan S. Iwanczyk, Photon Imaging, Inc. (United States)
Andrew B. Hwang, Univ. of California/San Francisco (United States)
Univ. of California/Berkeley (United States)
Max C. Wu, Univ. of California/San Francisco (United States)
Bruce H. Hasegawa, Univ. of California/San Francisco (United States)
Univ. of California/Berkeley (United States)


Published in SPIE Proceedings Vol. 4786:
Penetrating Radiation Systems and Applications IV
H. Bradford Barber; Hans Roehrig; F. Patrick Doty; Lisa J. Porter; Edward J. Morton, Editor(s)

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