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Proceedings Paper

Adaptation of spectroscopic tools from high-throughput screening of combinatorial chemistry libraries to process chemical analysis
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Paper Abstract

This paper summarizes our recent activities to develop analytical spectroscopic tools for high-throughput screening (HTS) of combinatorial chemistry libraries and the adaptation of the developed techniques to more traditional, i.e., laboratory and manufacturing, scales. It is shown that, for a broad variety of applications, optical spectroscopic detection methods have a suite of attractive features that make them almost ideal HTS tools. Strategies for the development of new high-throughput screening tools are presented, followed by analysis of requirements for development of multivariate data analysis methods for prediction of properties of combinatorial materials, determination of contributing factors to combinatorial-scale chemical reactions using evolving factor analysis and multivariate curve resolution chemometric methods, high- throughput optimization of process parameters, and applicability of the developed HTS tools for in-line monitoring of scaled-up reactions.

Paper Details

Date Published: 14 February 2002
PDF: 12 pages
Proc. SPIE 4578, Fiber Optic Sensor Technology and Applications 2001, (14 February 2002); doi: 10.1117/12.456106
Show Author Affiliations
Radislav A. Potyrailo, GE Corporate Research and Development Ctr. (United States)

Published in SPIE Proceedings Vol. 4578:
Fiber Optic Sensor Technology and Applications 2001
Michael A. Marcus; Brian Culshaw, Editor(s)

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