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Proceedings Paper

Anti-biofouling coatings for optical fiber sensors
Author(s): Anna Grazia Mignani; P. Bizzarri; M. Driver; R. Palmer; K. Liefeith; G. Hildebrand; John P. Dakin
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Paper Abstract

One of the most serious problems relevant to the use of optical fiber sensors in real-world environments is surface fouling, that is, the cumulative build-up of undesirable material on the working surface of a sensor. This paper present the results of anti-biofouling tests on coated fiber optic probes for reflectance spectroscopy in blood- simulating foul media, namely Bovine Serum Albumin (BSA) and Fibrinogen. The anti-biofouling coating, a proprietary invention of Biocompatibles Ltd., was a cross-linkable Phosphorylcholine (PC) polymer with Silane functionality, to improve adhesion to silica-containing substrates. All tests in BSA and Fibrinogen showed that PC-1036 coating was efficient in avoiding the build-up of biological material. In fact, optical signal variations of un-coated probes showed fluctuations in the 6-20% range, while coated probes exhibited a nearly-stable optical signal. These results were also confirmed by a microscopic check, which showed adhesions of biological material to un-coated probes.

Paper Details

Date Published: 14 February 2002
PDF: 8 pages
Proc. SPIE 4578, Fiber Optic Sensor Technology and Applications 2001, (14 February 2002); doi: 10.1117/12.456095
Show Author Affiliations
Anna Grazia Mignani, Istituto di Ricerca sulle Onde Elettromagnetiche (Italy)
P. Bizzarri, Istituto di Ricerca sulle Onde Elettromagnetiche (Italy)
M. Driver, Biocompatibles Ltd. (United Kingdom)
R. Palmer, Biocompatibles Ltd. (United Kingdom)
K. Liefeith, Institut fuer Bioprozess und Analysenmesstechnik (Germany)
G. Hildebrand, Institut fuer Bioprozess und Analysenmesstechnik (Germany)
John P. Dakin, Univ. of Southampton (United Kingdom)

Published in SPIE Proceedings Vol. 4578:
Fiber Optic Sensor Technology and Applications 2001
Michael A. Marcus; Brian Culshaw, Editor(s)

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