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Proceedings Paper

Simulation of the force-distance curves of atomic force microscopy for proteins by the Connolly surface approach
Author(s): Jinan Cao; Duy K. Pham; Livia Tonge; Dan V. Nicolau
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Paper Abstract

An attempt to simulate the interaction between an AFM tip and a protein surface by employing the concept of Connolly molecular surface with a carbon probe has been investigated. A methodology has been developed to permit the computation of the Connolly surface for a protein, where numerous atoms are simultaneously interacting each other. The van der Waals and electrostatic interactions between the probe and the relevant Connolly surface elements are integrated to obtain the total interaction, resulting in a precise theoretical account for a variety of interaction components. The simulation offers a meaningful opportunity for AFM scientists to interpret AFM surface mapping results more precisely or on a more general level the polymer surface-protein surface interactions.

Paper Details

Date Published: 19 November 2001
PDF: 8 pages
Proc. SPIE 4590, BioMEMS and Smart Nanostructures, (19 November 2001); doi: 10.1117/12.454603
Show Author Affiliations
Jinan Cao, Swinburne Univ. of Technology (Australia)
Duy K. Pham, Swinburne Univ. of Technology (Australia)
Livia Tonge, Swinburne Univ. of Technology (Australia)
Dan V. Nicolau, Swinburne Univ. of Technology (Australia)


Published in SPIE Proceedings Vol. 4590:
BioMEMS and Smart Nanostructures
Laszlo B. Kish; Erol C. Harvey; William B. Spillman, Editor(s)

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