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Proceedings Paper

3D micro-CT analysis of cancellous bone architecture
Author(s): Massimo Rossi; Franco Casali; Davide Romani; Maria Letizia Carabini
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Paper Abstract

Osteoporosis is the most common type of metabolic bone disease generating morphological alterations of the bone structure. Therefore, an intensive and accurate study of cancellous bone architecture is required to individuate the origin of the disease and to estimate its evolution. For this purpose, a specific project is in progress at the Physics Department of Bologna to carry out microtomography analysis in vitro of animal bone samples. The inspection system mainly consists of an X-ray microfocus source to irradiate the sample and of a CCD-based detector for the detection of the radiographic image. A sample with a diameter up to 30 mm and a height of 15 mm can be investigated over its whole volume. Three-dimensional images of the bone structure can be obtained with a spatial resolution variable from 30 up to few microns. A pig bone specimen has been investigated to test the equipment and to carry out intensive analysis and modeling of bone architecture. Moreover, a specific volume data processing procedure has been developed and tested to extract morphometric measurements of the bone structure.

Paper Details

Date Published: 7 January 2002
PDF: 10 pages
Proc. SPIE 4503, Developments in X-Ray Tomography III, (7 January 2002); doi: 10.1117/12.452863
Show Author Affiliations
Massimo Rossi, Univ. degli Studi di Bologna (Italy)
Franco Casali, Univ. degli Studi di Bologna (Italy)
Davide Romani, Univ. degli Studi di Bologna (Italy)
Maria Letizia Carabini, Univ. degli Studi di Bologna (Italy)

Published in SPIE Proceedings Vol. 4503:
Developments in X-Ray Tomography III
Ulrich Bonse, Editor(s)

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