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Proceedings Paper

Nondestructive three-dimensional evaluation of biocompatible materials by microtomography using synchrotron radiation
Author(s): Bert Muller; Philipp Thurner; Felix Beckmann; Timm Weitkamp; Christoph Rau; Ricardo Bernhardt; Erdal Karamuk; Ludwig Eckert; J. Brandt; Stefan Buchloh; Erich Wintermantel; Dieter Scharnweber; Hartmut Worch
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Paper Abstract

Microtomography based on synchrotron radiation sources is a unique technique for the 3D characterization of different materials with a spatial resolution down to about 1 micrometers . The interface between implant materials (metals, ceramics and polymers) and biological matter is nondestructively accessible, i.e. without preparation artifacts. Since the materials exhibit different x-ray absorption, it can become impossible to visualize implant material and tissue, simultaneously. Here, we show that coating of polymer implants, which are invisible in bone tissue, does not only improve the interfacial properties but also allows the imaging of the interface in detail. Titanium implants, on the other hand, absorb the x-rays stronger than bone tissue. The difference, however, is small enough to quantify the bone formation near interface. Another advantage of microtomography with respect to classical histology is the capability to examine samples in a hydrated state. We demonstrate that ceramic hollow spheres can be imaged before sintering and fibroblasts marked by OsO4 are visible on polymer textiles. Consequently, scaffolds of different materials designed for tissue engineering and implant coatings can be optimized on the basis of the tomograms.

Paper Details

Date Published: 7 January 2002
PDF: 11 pages
Proc. SPIE 4503, Developments in X-Ray Tomography III, (7 January 2002); doi: 10.1117/12.452843
Show Author Affiliations
Bert Muller, ETH Zurich (Switzerland)
Philipp Thurner, Swiss Federal Labs. for Materials/Duebendorf (Switzerland)
Felix Beckmann, Deutsches Elektronen-Synchrotron/HASYLAB (Germany)
Timm Weitkamp, European Synchrotron Radiation Facility (France)
Christoph Rau, European Synchrotron Radiation Facility (France)
Ricardo Bernhardt, Technische Univ. Dresden (Germany)
Erdal Karamuk, ETH Zurich (Switzerland)
Ludwig Eckert, ETH Zurich (Switzerland)
J. Brandt, Martin-Luther-University Halle-Wittenberg (Germany)
Stefan Buchloh, ETH Zurich (Switzerland)
Erich Wintermantel, ETH Zurich (Germany)
Dieter Scharnweber, Technische Univ. Dresden (Germany)
Hartmut Worch, Technische Univ. Dresden (Germany)


Published in SPIE Proceedings Vol. 4503:
Developments in X-Ray Tomography III
Ulrich Bonse, Editor(s)

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