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Proceedings Paper

Metal nanoparticles for biodetection
Author(s): Steven Oldenburg; Jack Mock; James R. Glass; Ana B. Asenjo; Christine C. Genick; David R. Smith; David A. Schultz; Sheldon Schultz
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Paper Abstract

The large scattering cross section of plasmon resonant gold and silver nanoparticles functionalized with the appropriate ligand allows for sensitive and specific detection of nucleic acids and proteins. By varying the size, shape, and material morphology populations with a specific peak plasmon resonance can be prepared. By varying the order and length of plasmon resonant bar segment in a composite nanowire one can obtain a large number of particle populations. Distinct populations can be used for labels for multiplexing or as a platform for biological assays. An larger number of color populations can be obtained with composite nanowires that are fabricated with various lengths of silver, gold, or nickel segments. The order and length of the different plasmon resonance rod segments can be used to uniquely identify a rod population allowing for a large degree of multiplexing within a single sample.

Paper Details

Date Published: 4 October 2002
PDF: 6 pages
Proc. SPIE 4810, Properties of Metal Nanostructures, (4 October 2002); doi: 10.1117/12.450805
Show Author Affiliations
Steven Oldenburg, Seashell Technology (United States)
Jack Mock, Univ. of California/San Diego (United States)
James R. Glass, Seashell Technology (United States)
Ana B. Asenjo, Seashell Technology (United States)
Christine C. Genick, Seashell Technology (United States)
David R. Smith, Univ. of California/San Diego (United States)
David A. Schultz, Univ. of California/San Diego (United States)
Sheldon Schultz, Univ. of California/San Diego (United States)


Published in SPIE Proceedings Vol. 4810:
Properties of Metal Nanostructures
Naomi J. Halas, Editor(s)

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