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Proceedings Paper

Weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology
Author(s): Jean A. Laissue; Hans Blattmann; Marco Di Michiel; Daniel N. Slatkin; Nadia Lyubimova; Raphael Guzman; Werner Zimmermann; Stephan Birrer; Tim Bley; Patrick Kircher; Regina Stettler; Rosmarie Fatzer; Andre Jaggy; Henry Smilowitz; Elke Brauer; Alberto Bravin; Geraldine Le Duc; Christian Nemoz; Michel Renier; William C. Thomlinson; Jiri Stepanek; Hans-Peter Wagner
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Paper Abstract

The cerebellum of the weanling piglet (Yorkshire) was used as a surrogate for the radiosensitive human infant cerebellum in a Swiss-led program of experimental microbeam radiation therapy (MRT) at the ESRF. Five weanlings in a 47 day old litter of seven, and eight weanlings in a 40 day old litter of eleven were irradiated in November, 1999 and June, 2000, respectively. A 1.5 cm-wide x 1.5 xm-high array of equally space approximately equals 20-30 micrometers wide, upright microbeams spaced at 210 micrometers intervals was propagated horizontally, left to right, through the cerebella of the prone, anesthetized piglets. Skin-entrance intra-microbeam peak adsorbed doses were uniform, either 150, 300, 425, or 600 gray (Gy). Peak and inter-microbeam (valley) absorbed doses in the cerebellum were computed with the PSI version of the Monte Carlo code GEANT and benchmarked using Gafchromic and radiochromic film microdosimetry. For approximately equals 66 weeks [first litter; until euthanasia], or approximately equals 57 weeks [second litter; until July 30, 2001] after irradiation, the littermates were developmentally, behaviorally, neurologically and radiologically normal as observed and tested by experienced farmers and veterinary scientists unaware of which piglets were irradiated or sham-irradiated. Morever, MRT implemented at the ESRF with a similar array of microbeams and a uniform skin-entrance peak dose of 625 Gy, followed by immunoprophylaxis, was shown to be palliative or curative in young adult rats bearing intracerebral gliosarcomas. These observations give further credence to MRT's potential as an adjunct therapy for brain tumors in infancy, when seamless therapeutic irradiation of the brain is hazardous.

Paper Details

Date Published: 19 December 2001
PDF: 9 pages
Proc. SPIE 4508, Penetrating Radiation Systems and Applications III, (19 December 2001); doi: 10.1117/12.450774
Show Author Affiliations
Jean A. Laissue, Univ. Bern (Switzerland)
Hans Blattmann, Paul Scherrer Institute (Switzerland)
Marco Di Michiel, European Synchrotron Radiation Facility (France)
Daniel N. Slatkin, Univ. Bern (United States)
Nadia Lyubimova, Univ. Bern (Switzerland)
Raphael Guzman, Univ. Bern (Switzerland)
Werner Zimmermann, Univ. Bern (Switzerland)
Stephan Birrer, Univ. Bern (Switzerland)
Tim Bley, Univ. Bern (Switzerland)
Patrick Kircher, Univ. Bern (Switzerland)
Regina Stettler, Univ. Bern (Switzerland)
Rosmarie Fatzer, Univ. Bern (Switzerland)
Andre Jaggy, Univ. Bern (Switzerland)
Henry Smilowitz, Univ. of Connecticut Health Ctr. (United States)
Elke Brauer, European Synchrotron Radiation Facility (France)
Alberto Bravin, European Synchrotron Radiation Facility (France)
Geraldine Le Duc, European Synchrotron Radiation Facility (France)
Christian Nemoz, European Synchrotron Radiation Facility (France)
Michel Renier, European Synchrotron Radiation Facility (France)
William C. Thomlinson, European Synchrotron Radiation Facility (France)
Jiri Stepanek, Paul Scherrer Institute (Switzerland)
Hans-Peter Wagner, Univ. Bern (Switzerland)

Published in SPIE Proceedings Vol. 4508:
Penetrating Radiation Systems and Applications III
H. Bradford Barber; Hans Roehrig; F. Patrick Doty; Richard C. Schirato; Edward J. Morton, Editor(s)

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