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Proceedings Paper

Three-dimensional optical tomographic imaging of vascular reactivity in the brain
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Paper Abstract

We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

Paper Details

Date Published: 2 November 2001
PDF: 12 pages
Proc. SPIE 4431, Photon Migration, Optical Coherence Tomography, and Microscopy, (2 November 2001); doi: 10.1117/12.447424
Show Author Affiliations
Andreas H. Hielscher, SUNY/Downstate Medical Ctr., and Polytechnic Univ. (United States)
Avraham Bluestone, SUNY/Downstate Medical Ctr. (United States)
Gassan S. Abdoulaev, SUNY/Downstate Medical Ctr. (United States)
Joseph Lasker, SUNY/Downstate Medical Ctr., and Polytechnic Univ. (United States)
Randall Locke Barbour, SUNY/Downstate Medical Ctr., and Polytechnic Univ. (United States)
Christoph H. Schmitz, SUNY/Downstate Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 4431:
Photon Migration, Optical Coherence Tomography, and Microscopy
Stefan Andersson-Engels; Michael F. Kaschke, Editor(s)

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