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Proceedings Paper

Spectral characteristic analysis of lung cancer serum
Author(s): Xiao Zhou Li; Huiqiang Jin; Huasheng Liu; Jianhua Ding; Junxiu Lin
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Paper Abstract

Spectral changes of lung cancer serum in the process of tumor evolution were investigated in this study. We kept close watch on the tumor progression of a group of patients, and measured their serum spectra using 488.0nm and 514.5nm excitation of an Ar-ion laser once a week. There was no apparent change observed in fluorescence spectrum in different period. However, the relative intensity of three Raman peaks (mode A, B and C) decreased every week later. For quantitative analysis of such changes, a parameter Ir (relative intensity of C Raman peak) was introduced and Ir-value was calculated. Calculation showed that Ir-value was degressive with tumor evolution, but (beta) (Ir5145 /Ir4880) varied irregularly. To the end, no Raman peak was observed. We assumed that three Raman peaks were derived from beta carotene. It indicated that the content of beta carotene decreased with the aggravation of lung cancer.

Paper Details

Date Published: 31 October 2001
PDF: 6 pages
Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); doi: 10.1117/12.447146
Show Author Affiliations
Xiao Zhou Li, Tsinghua Univ. (China)
Huiqiang Jin, Shenyang Institute of Technology (China)
Huasheng Liu, Dalian Univ. of Technology (China)
Jianhua Ding, Dalian Univ. of Technology (China)
Junxiu Lin, Dalian Univ. of Technology (China)


Published in SPIE Proceedings Vol. 4432:
Diagnostic Optical Spectroscopy in Biomedicine
Theodore G. Papazoglou; Georges A. Wagnieres, Editor(s)

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