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Proceedings Paper

Optical detection of (pre-)malignant lesions of the oral mucosa: autofluorescence characteristics of healthy mucosa
Author(s): Diana C. G. de Veld; Max Witjes; Jan L.N. Roodenburg; Willem M. Star; Hericus J. C. M. Sterenborg
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Paper Abstract

Previous clinical results demonstrate the potential of in vivo autofluorescence spectroscopy for early detection of (pre-)malignant lesions of the oral mucosa. For reliable diagnosis, it is necessary to study autofluorescence spectra of healthy mucosa first. We measured excitation-emission maps in healthy subjects and subjects with a history of cancer in the head -neck region. Our results show that different anatomical locations produce distinct autofluorescence spectra. Influences of, among others, smoking and drinking habits require further investigation.

Paper Details

Date Published: 31 October 2001
PDF: 3 pages
Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); doi: 10.1117/12.447135
Show Author Affiliations
Diana C. G. de Veld, Univ. Hospital Groningen (Netherlands)
Max Witjes, Univ. Hospital Groningen (Netherlands)
Jan L.N. Roodenburg, Univ. Hospital Groningen (Netherlands)
Willem M. Star, Univ. Hospital Rotterdam (Netherlands)
Hericus J. C. M. Sterenborg, Univ. Hospital Rotterdam (Netherlands)

Published in SPIE Proceedings Vol. 4432:
Diagnostic Optical Spectroscopy in Biomedicine
Theodore G. Papazoglou; Georges A. Wagnieres, Editor(s)

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