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Proceedings Paper

Trimodal spectroscopy as a tool for detecting cervical squamous intraepithelial lesions in vivo
Author(s): Irene Georgakoudi; Ellen E. Sheets; Christopher P. Crum; Markus G. Mueller; Vadim Backman; Michael S. Feld
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Paper Abstract

Using intrinsic fluorescence, diffuse reflectance and light scattering spectroscopy we extracted quantitative biochemical and morphological information in vivo about the bulk tissue and the epithelial cell nuclei of ectocervical sites from 44 patients. Significant changes were observed in tissue morphology and biochemistry between normal, squamous metaplastic and squamous intraepithelial lesion (SIL) sites. The combined use of all three spectroscopic techniques (tri-modal spectroscopy) yielded superior results for detecting SILs than any one of the techniques alone.

Paper Details

Date Published: 31 October 2001
PDF: 9 pages
Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); doi: 10.1117/12.447118
Show Author Affiliations
Irene Georgakoudi, Massachusetts Institute of Technology (United States)
Ellen E. Sheets, Brigham & Women's Hospital/Harvard Medical School (United States)
Christopher P. Crum, Brigham & Women's Hospital/Harvard Medical School (United States)
Markus G. Mueller, Massachusetts Institute of Technology (United States)
Vadim Backman, Massachusetts Institute of Technology (United States)
Michael S. Feld, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 4432:
Diagnostic Optical Spectroscopy in Biomedicine
Theodore G. Papazoglou; Georges A. Wagnieres, Editor(s)

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