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Proceedings Paper

DNA binding of supramolecular mixed-metal complexes
Author(s): Shawn Swavey; Rodd Lee Williams; Zhenglai Fang; Matthew Milkevitch; Karen Jenks Brewer
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Paper Abstract

The high binding affinity of cisplatin toward DNA has led to its popularity as an anticancer agent. Due to cumulative drug resistance and toxic side effects, researchers are exploring related metallodrugs. Our approach involves the use of supramolecular complexes. These mixed-metal complexes incorporate a reactive platinum moiety bridged by a polyazine ligand to a light absorbing metal-based chromophore. The presence of the light absorber allows excitation of these systems, opening up the possibility of photoactivation. The use of a supramolecular design allows components of the assembly to be varied to enhance device function and light absorbing properties. Aspects of our molecular design process and results on the DNA binding properties for a number of these mixed-metal complexes will be discussed.

Paper Details

Date Published: 23 October 2001
PDF: 9 pages
Proc. SPIE 4512, Complex Adaptive Structures, (23 October 2001); doi: 10.1117/12.446779
Show Author Affiliations
Shawn Swavey, Virginia Polytechnic Institute and State Univ. (United States)
Rodd Lee Williams, Virginia Polytechnic Institute and State Univ. (United States)
Zhenglai Fang, Virginia Polytechnic Institute and State Univ. (United States)
Matthew Milkevitch, Virginia Polytechnic Institute and State Univ. (United States)
Karen Jenks Brewer, Virginia Polytechnic Institute and State Univ. (United States)


Published in SPIE Proceedings Vol. 4512:
Complex Adaptive Structures

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