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Proceedings Paper

Laser-induced photodynamic effect
Author(s): Hana Kolarova; Roman Kubinek; Leos Navratil; Miroslav Strnad; Kamila Reblova; Jiri Skopek
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Paper Abstract

Photodynamic therapy is a treatment that is used for destruction of certain tumors. The treatment is performed with photosensitizers that generate reactive oxygen species in the presence of light and oxygen. The absorption and fluorescence spectra of the ClAlPcS2 and ZnPcS2 photosensitizers were measured. From this analysis a semiconductor laser emitting a beam of 50 mW cw power at the wavelength of 675 nm for our experiments was chosen, because this wavelength corresponded with the absorption maximum (675 nm) in long-wave region of the visible part of electromagnetic spectra. B16 (cells line of mouse melanoma) was chosen as a standard testing system for definition of the in vitro phototoxicity after photodynamic reaction. The optimal phototoxic effect on B16 cells was observed at 2 (mu) g/ml ClAlPcS2 in combination with laser irradiation of 10 J/cm2.

Paper Details

Date Published: 23 October 2001
PDF: 4 pages
Proc. SPIE 4606, Laser Florence 2000: A Window on the Laser Medicine World, (23 October 2001); doi: 10.1117/12.446710
Show Author Affiliations
Hana Kolarova, Palacky Univ. (Czech Republic)
Roman Kubinek, Palacky Univ. (Czech Republic)
Leos Navratil, Charles Univ. (Czech Republic)
Miroslav Strnad, Palacky Univ. (Czech Republic)
Kamila Reblova, Palacky Univ. (Czech Republic)
Jiri Skopek, Charles Univ. (Czech Republic)

Published in SPIE Proceedings Vol. 4606:
Laser Florence 2000: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R.A. Waidelich, Editor(s)

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