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Proceedings Paper

Optical properties of cytostatic drugs used in cancer treatment
Author(s): Mihail-Lucian Pascu; Ioan Mogos; Mironel Enescu; Angela Staicu; Sorina Truica; Letitia Voicu; Doina M. Gazdaru; Mihaela Oana Pascu; Alina Radu
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Paper Abstract

A spectroscopical characterization of methotrexate, cytostatic drug used frequently in cancer therapy, was performed. The absorption, emission and excitation spectra were measured for methotrexate solutions in natural saline and sodium hydroxide at concentration in the range 10-5 M -10-6 M and pH 8.4. The absorption bands are noticed in the spectral range 250 nm - 450 nm. The fluorescence excitation was made at 340 nm and 370 nm; the fluorescence emission was detected in the spectral range 400 nm - 500 nm with a maximum at 450 nm. The behavior of absorption and fluorescence spectra of methotrexate solution exposed to uv-visible light was investigated. The irradiation was made using an Xe lamp (emission between 325 nm and 420 nm and power density of 11 mW/cm2). The exposure time was between 15 min. and 3 h. Major modifications on absorption bands for irradiation times longer than 1 hour were observed. Furthermore, the methotrexate solutions become strongly fluorescent after irradiation. The observed changes are not linear with the exposure time indicating complex photochemical processes which implies, at least, one intermediate product.

Paper Details

Date Published: 23 October 2001
PDF: 6 pages
Proc. SPIE 4606, Laser Florence 2000: A Window on the Laser Medicine World, (23 October 2001); doi: 10.1117/12.446699
Show Author Affiliations
Mihail-Lucian Pascu, National Institute for Lasers, Plasma and Radiation Physics (Romania)
Ioan Mogos, Alexandru Trestioreanu Oncology Institute (Romania)
Mironel Enescu, National Institute for Lasers, Plasma and Radiation Physics (Romania)
Angela Staicu, National Institute for Lasers, Plasma and Radiation Physics (Romania)
Sorina Truica, National Institute for Lasers, Plasma and Radiation Physics (Romania)
Letitia Voicu, National Institute for Lasers, Plasma and Radiation Physics (Romania)
Doina M. Gazdaru, Univ. of Bucharest (Romania)
Mihaela Oana Pascu, Dimitrie Gerota Military Emergency Hospital (Romania)
Alina Radu, Theodor Burghele Hospital (Romania)


Published in SPIE Proceedings Vol. 4606:
Laser Florence 2000: A Window on the Laser Medicine World

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