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Proceedings Paper

Chemiluminescence detection from sonodynamic action in vitro and in vivo
Author(s): Yonghong He; Da Xing; Guihong Yan; Ken-ichi Ueda
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Paper Abstract

In this work, chemiluminescence method was engaged for the first time to detect the active oxygen spices during sonocynamic action both in vitro and in vivo. We used CLA derivatives, which can efficiently react with singlet oxygen (1O2) or superoxide anion (O2-) to emit light, and luminol, which can be oxidized by a variety of free radicals to emit photons, to real-timely detect oxygen free radical formation in the sonosensitization of two sonosensitizer ATX-70 and HpD. The results show that 1O2 is involved in the sonosensitization. The mechanism of sonosensitizing was discussed. In vivo experiments, tumor imaging by sonodynamic chemiluminescence detection methods was established. This method could have potential applications in clinics for early-stage tumor diagnosis.

Paper Details

Date Published: 25 October 2001
PDF: 8 pages
Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); doi: 10.1117/12.446658
Show Author Affiliations
Yonghong He, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)
Guihong Yan, South China Normal Univ. (China)
Ken-ichi Ueda, Univ. of Electro-Communications (Japan)

Published in SPIE Proceedings Vol. 4597:
Biophotonics Instrumentation and Analysis
Arthur E. T. Chiou; Halina Podbielska; Steven L. Jacques, Editor(s)

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