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Proceedings Paper

Endoscopy imaging of 5-ALA-induced PPIX fluorescence for detecting early neoplasms in the oral cavity
Author(s): Wei Zheng; Malini Olivo; Ranjiv Sivanandan; Philip Karuman; Tuan-Kay Lim; K. Chee Soo
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Paper Abstract

A digitized fluorescence endoscopy imaging system combined with 5-Aminolevulinic Acid (5-ALA) induced Protoporphyrin IX (PPIX) has been developed for the detection of neoplasms in oral cavity. It mainly consists of the illumination console, fluorescence detection unit, computer system for image acquisition, processing and analysis, and online image display system as well. The developed system can produce both the digital and video fluorescence images in real time, and can be used to quantify fluorescence images acquired. Preliminary results from the Head and Neck clinic show that high sensitivity and high specificity can be achieved. Furthermore, applying the intensity ratios at two different wavelength regions, the developed system shows the capability of differentiating between different histopathological stages of oral lesions, suggesting a significant potential for realizing the non-invasive optical biopsy for early cancer diagnosis.

Paper Details

Date Published: 25 October 2001
PDF: 5 pages
Proc. SPIE 4597, Biophotonics Instrumentation and Analysis, (25 October 2001); doi: 10.1117/12.446648
Show Author Affiliations
Wei Zheng, National Cancer Ctr. (Singapore)
Malini Olivo, National Cancer Ctr. (Singapore)
Ranjiv Sivanandan, Singapore General Hospital (Singapore)
Philip Karuman, National Cancer Ctr. (Singapore)
Tuan-Kay Lim, Nanyang Technological Univ. (Singapore)
K. Chee Soo, National Cancer Ctr. and Singapore General Hospital (Singapore)

Published in SPIE Proceedings Vol. 4597:
Biophotonics Instrumentation and Analysis
Arthur E. T. Chiou; Halina Podbielska M.D.; Steven L. Jacques, Editor(s)

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