Share Email Print
cover

Proceedings Paper

PUVB-mediated prevention of luminal narrowing after arterial wall injury: modulation of mechanical arterial properties as a putative mechanism of action
Author(s): Jop Perree; Raphaela P.A. Kerindongo; Ton G. J. M. van Leeuwen
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In a previous study we have found that the photodynamic modality PUVB (8-methoxy-Psoralen + UVB) reduces luminal narrowing after arterial endovascular injury. We hypothesized that PUVB may modulate the arterial mechanical properties and tested this hypothesis by measuring the stress as a function of the strain in segments of carotid artery. Furthermore, we have investigated the potential for PUVB-induced cross-linking of extracellular matrix proteins by gel electrophoresis. It was found that both techniques were suitable for testing our hypotheses as evidenced by a statistically significant difference for the positive control. However, no differences between A) control, B) sensitizer only, C) light only and D) PUVB-treated samples could be found with respect to macro- and micro-mechanical properties. Therefore, the hypothesis that PUVB mediates its luminal narrowing reduction effect by directly changing the arterial mechanical properties should be rejected.

Paper Details

Date Published: 26 October 2001
PDF: 5 pages
Proc. SPIE 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy, (26 October 2001); doi: 10.1117/12.446528
Show Author Affiliations
Jop Perree, Academic Medical Ctr./Interuniv. Cardiology Institute of the Netherlands (Netherlands)
Raphaela P.A. Kerindongo, Academic Medical Ctr./Interuniv. Cardiology Institute of the Netherlands (Netherlands)
Ton G. J. M. van Leeuwen, Academic Medical Ctr./Interuniv. Cardiology Institute of the Netherlands (Netherlands)


Published in SPIE Proceedings Vol. 4433:
Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy
Reginald Birngruber; Hubert van den Bergh, Editor(s)

© SPIE. Terms of Use
Back to Top