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Proceedings Paper

Application of phosphorescence quenching by O2 to the investigation of O2 delivery to ocular tissues
Author(s): Stephane R. Chamot; Benno L. Petrig; Constantin J. Pournaras; Christine L. Percicot; George N. Lambrou; Charles E. Riva
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Paper Abstract

The technique of phosphorescence quenching by O2 (PQ) allows the non-invasive measurement of the partial pressure of oxygen in blood (pO2blood). This technique and its application to the investigation of the pO2blood in the microvasculature of the retina and optic nerve head (ONH) of two animal species is described. Using the imaging mode of PQ, 2-dimensional pO2blood maps were obtained to investigate the response of the pO2blood to various physiological stimuli in miniature pigs and the effect of experimental glaucoma in monkeys. Applied in its focal mode, PQ allows measurements of the pO2blood with a time resolution of 1 second and is adequate to investigate the pO2blood time course during light stimulation.

Paper Details

Date Published: 26 October 2001
PDF: 9 pages
Proc. SPIE 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy, (26 October 2001); doi: 10.1117/12.446498
Show Author Affiliations
Stephane R. Chamot, Institut de Recherche en Ophtalmologie (Switzerland)
Benno L. Petrig, Institut de Recherche en Ophtalmologie (Switzerland)
Constantin J. Pournaras, Univ. Eye Clinic (Switzerland)
Christine L. Percicot, Novartis Ophthalmics Research (Switzerland)
George N. Lambrou, Novartis Ophthalmics Research (Switzerland)
Charles E. Riva, Institut de Recherche en Ophtalmologie and Univ. of Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 4433:
Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy
Reginald Birngruber; Hubert van den Bergh, Editor(s)

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