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Proceedings Paper

Vascular anastomosis using a pulsed diode laser
Author(s): Douglas Deford; Adam Higgins; Kenton W. Gregory M.D.
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Paper Abstract

The objective of this research is to provide a novel approach to the problem of vascular anastomosis. The work subscribes to the idea that if we use a human protein that has adhesive properties, denatures by heat in an irreversible way and forms a semi-hard but flexible matter. Also belongs to the circulatory system, is liquid in its native state , and after denaturing it is not soluble inwater, blood plasma or any other related fluids anymore. Therefore, a pulsed diode laser beam can be used on this protein in order to have a strong welding for vascular anastomosis. It was established in the Oregon Medical Laser Center that the best proteins to be used , as a welding biomaterial, is human albumin. Indocyanine Green was added to provide a compound that absorbs light and transforms it in heat to the denaturing and welding process. Tests with liquid albumin were performed, the results obtained were unreliable due to the following facts: the variation in the liquid film thickness produced pockets of native (non-denatured albumin) underneath the denatured welded crust and bubbles produced by water evaporation. This phenomenon led to a weak welding. After testing different options, it was decided that the manufacturing of asolid thin film of albumin/ICG with a content of water between 37-40% was the best option. It reduces the number of bubbles, and provides a constant thickness between 200-250 ?m. This thin film can be used alone on the vascular surface to be welded , or in combination with an elastin strip to increase strength. To avoid collapsing of the blood vessel while welding, and also keep both edges of the vessel together, an albumin/ICG stent was designed so the configuration of the stent does not allow the vessel to slip away or collapse. The stent is made out of native human albumin with water content between 37-40%. When the weld is completed and the forceps are released, it is expected that the natural flow of blood will dissolve the stent in less than 12 minutes (according with experiments already performed with lukewarm water).

Paper Details

Date Published: 17 June 2002
PDF: 7 pages
Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.444382
Show Author Affiliations
Douglas Deford
Adam Higgins

Published in SPIE Proceedings Vol. 4609:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
Lawrence S. Bass M.D.; Eugene A. Trowers M.D.; Kenneth Eugene Bartels D.V.M.; Udayan K. Shah M.D.; David S. Robinson M.D.; Lawrence S. Bass M.D.; Kenton W. Gregory M.D.; Kenneth Eugene Bartels D.V.M.; Lawrence S. Bass M.D.; Brian Jet-Fei Wong M.D.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; Nikiforos Kollias; Abraham Katzir; Timothy A. Woodward M.D.; Werner T.W. de Riese; George M. Peavy D.V.M.; Werner T.W. de Riese; Kenton W. Gregory M.D.; Michael D. Lucroy D.V.M.; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy D.V.M.; Reza S. Malek M.D.; George M. Peavy; Hans-Dieter Reidenbach; David S. Robinson M.D.; Udayan K. Shah M.D.; Lloyd P. Tate V.D.M.; Eugene A. Trowers M.D.; Brian Jet-Fei Wong M.D.; Timothy A. Woodward M.D., Editor(s)

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