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Proceedings Paper

Animal on a chip: a microscale cell culture analog device for evaluating toxicological and pharmacological profiles
Author(s): Aaron Sin; Gregory T. Baxter; Michael L. Shuler
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Paper Abstract

With the increasing rate of discovery of new potential pharmaceuticals, an accurate high throughput screening method is needed to provide toxicology and pharmcology profiles of chemicals. This can be done using a cell culture analog device which uses interconnected tissue cultures to represent different organ systems in animals. A working prototype of microscale cell culture analog (CCA) device has been constructed. Cells cultured in the system have been shown to be viable for more than 24 hours. In this paper, we will present the development of this microscale CCA device as well as the integratable micropump we have created to produce the recirculating flow.

Paper Details

Date Published: 28 September 2001
PDF: 4 pages
Proc. SPIE 4560, Microfluidics and BioMEMS, (28 September 2001); doi: 10.1117/12.443045
Show Author Affiliations
Aaron Sin, Cornell Univ. (United States)
Gregory T. Baxter, Cornell Univ. (United States)
Michael L. Shuler, Cornell Univ. (United States)

Published in SPIE Proceedings Vol. 4560:
Microfluidics and BioMEMS
Carlos H. Mastrangelo; Holger Becker, Editor(s)

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