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Proceedings Paper

Microfluidic sample preparation for immunoassays
Author(s): Steven R. Visuri; William J. Benett; Kerry Bettencourt; John Chang; Karl A. Fisher; Julia Hamilton; Peter A. Krulevitch; Christina S. Park; Cheryl A. Stockton; Lisa A. Tarte; Amy Wang; Thomas Wilson
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Paper Abstract

Researchers at Lawrence Livermore National Laboratory are developing means to collect and identify fluid-based biological pathogens in the forms of proteins, viruses, and bacteria. To support detection instruments, we are developing a flexible fluidic sample preparation unit. The overall goal of this Microfluidic Module is to input a fluid sample, containing background particulates and potentially target compounds, and deliver a processed sample for detection. We are developing techniques for sample purification, mixing, and filtration that would be useful to many applications including immunologic and nucleic acid assays. Many of these fluidic functions are accomplished with acoustic radiation pressure or dielectrophoresis. We are integrating these technologies into packaged systems with pumps and valves to control fluid flow through the fluidic circuit.

Paper Details

Date Published: 28 September 2001
PDF: 7 pages
Proc. SPIE 4560, Microfluidics and BioMEMS, (28 September 2001); doi: 10.1117/12.443043
Show Author Affiliations
Steven R. Visuri, Lawrence Livermore National Lab. (United States)
William J. Benett, Lawrence Livermore National Lab. (United States)
Kerry Bettencourt, Lawrence Livermore National Lab. (United States)
John Chang, Lawrence Livermore National Lab. (United States)
Karl A. Fisher, Lawrence Livermore National Lab. (United States)
Julia Hamilton, Lawrence Livermore National Lab. (United States)
Peter A. Krulevitch, Lawrence Livermore National Lab. (United States)
Christina S. Park, Lawrence Livermore National Lab. (United States)
Cheryl A. Stockton, Lawrence Livermore National Lab. (United States)
Lisa A. Tarte, Lawrence Livermore National Lab. (United States)
Amy Wang, Lawrence Livermore National Lab. (United States)
Thomas Wilson, Lawrence Livermore National Lab. (United States)


Published in SPIE Proceedings Vol. 4560:
Microfluidics and BioMEMS
Carlos H. Mastrangelo; Holger Becker, Editor(s)

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