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Proceedings Paper

Residue-producing E-filters and their applications in medical image analysis
Author(s): Kendall Preston
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Paper Abstract

Two recent Ph.D. theses by Lawrence Firestone and Norman Link, Carnegie Mellon University, treated subtyping follicular lymphomas (cancers of the human lymph node) from digital images of tissue sections mounted on microscope slides. To make the subtype differentiation by automated image analysis they examined many different features relating to spatial spectra, texture and texture energy, and three-dimensional morphology. The latter technique considers any gray-level image as a three-dimensional surface and uses three- dimensional erosions and dilations of this surface to extract features. Of all measures tested the best pair are both related to three-dimensional mathematical morphology. One of these was derived from residue-producing (Xi) -filters and is discussed in this paper. The (Xi) -filter selected measures surface voxels whose values are changed by the (Xi) -filter but for which no neighborhood voxel values are changed. Such filters have been found to be half-octave filters with steep cutoffs (60 dB per octave) exhibiting no phase shifts. These unusual filters are exactly matched to the subtype analysis of lymph-node cancers. (Xi) -filters are also valuable in other medical imaging applications. One of these applications is three-dimensional interpolation from serial sections. This application is also illustrated in this paper.

Paper Details

Date Published: 1 July 1991
PDF: 12 pages
Proc. SPIE 1450, Biomedical Image Processing II, (1 July 1991); doi: 10.1117/12.44285
Show Author Affiliations
Kendall Preston, Carnegie Mellon Univ. and Kensal Consulting (United States)

Published in SPIE Proceedings Vol. 1450:
Biomedical Image Processing II
Alan Conrad Bovik; Vyvyan Howard, Editor(s)

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